Steroid hormone action in eucaryotic cells.

Steroid hormone action in eucaryotic cells.

Visualizing the action of steroid hormone receptors in living cells

Transcription controlled by Steroid Hormone Receptors (SHRs) plays a key role in many important physiological processes like organ development, metabolite homeostasis, and response to external stimuli. Understandably, the members of this family have drawn a lot of attention from the scientific community since their discovery, four decades ago. Still, after many years of research we are only beg...

Plasma steroid-binding proteins: primary gatekeepers of steroid hormone action

Biologically active steroids are transported in the blood by albumin, sex hormone-binding globulin (SHBG), and corticosteroid-binding globulin (CBG). These plasma proteins also regulate the non-protein-bound or 'free' fractions of circulating steroid hormones that are considered to be biologically active; as such, they can be viewed as the 'primary gatekeepers of steroid action'. Albumin binds ...

Molecular Endocrinology and Steroid Hormone Action

potential application of the recent discoveries. For example, decreased expression of adhesion molecules may be a mechanism by which tumor cells escape immune surveillance. New therapeutic modalities are discussed, such as CD4 immunoadhesins for passive AIDS immunotherapy, and a urokinase-antifibrin conjugate that increases the fibrinolytic potency of urokinase. A particularly interesting chapt...

Molecular mechanisms of steroid hormone action.